|
Biliary Atresia
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Within the BA group, mRNA levels of TLRs 2 and 8 were significantly higher in the early group than in the late group (P = 0.02 and 0.006, respectively), despite there being no significant correlation between TLR mRNA expression and age at sampling, except for TLR7 (r = 0.77, P = 0.001).
|
21832949 |
2011 |
|
Congenital atresia of extrahepatic bile duct
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Within the BA group, mRNA levels of TLRs 2 and 8 were significantly higher in the early group than in the late group (P = 0.02 and 0.006, respectively), despite there being no significant correlation between TLR mRNA expression and age at sampling, except for TLR7 (r = 0.77, P = 0.001).
|
21832949 |
2011 |
|
Glomerulonephritis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
While multiple studies support the notion of a dependency on TLR-7 for disease development, genetic ablation of TLR-9 results in severe disease with glomerulonephritis (GN) by a largely unknown mechanism.
|
29687651 |
2018 |
|
Squamous cell carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Whereas the overall expression of TLR7 did not differ between BCC and SCC (30.4% vs. 45.8%, respectively), we found that within the group of SCC, the well-differentiated SCC showed strong tumoral and/or peritumoral immunocellular TLR7 reactivity in contrast to the poorly differentiated SCC (73.33% vs. 11.1%, respectively).
|
28857981 |
2017 |
|
Experimental Organism Basal Cell Carcinoma
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Whereas the overall expression of TLR7 did not differ between BCC and SCC (30.4% vs. 45.8%, respectively), we found that within the group of SCC, the well-differentiated SCC showed strong tumoral and/or peritumoral immunocellular TLR7 reactivity in contrast to the poorly differentiated SCC (73.33% vs. 11.1%, respectively).
|
28857981 |
2017 |
|
Carcinoma, Basal Cell
|
0.030 |
Biomarker
|
disease |
BEFREE |
Whereas the overall expression of TLR7 did not differ between BCC and SCC (30.4% vs. 45.8%, respectively), we found that within the group of SCC, the well-differentiated SCC showed strong tumoral and/or peritumoral immunocellular TLR7 reactivity in contrast to the poorly differentiated SCC (73.33% vs. 11.1%, respectively).
|
28857981 |
2017 |
|
Hepatitis C
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Whereas hepatic viral load and expression of genes known to be induced in chronic HCV infection were not found to differ in patients with wild-type or variant TLR7 rs179008 genotype, significant lower gene expression of interleukin-29 (IL-29)/lambda(1) interferon (IFN-λ(1)) and both of its receptor subunits was found for T homo- and hemizygous patients.
|
20872712 |
2010 |
|
Lupus Erythematosus, Systemic
|
0.300 |
Biomarker
|
disease |
BEFREE |
We will also elaborate on the recent evidence demonstrating that TLR7 escapes from X chromosome inactivation in the immune cells of women, and how this may contribute to endow woman immune system with enhanced responsiveness to RNA-virus and susceptibility to SLE.
|
31296302 |
2019 |
|
Dermatologic disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
We used the TLR7 agonist Imiquimod (IMQ) to induce a psoriasis-like skin disease in mice and found a strong downregulation of IL-22BP in the affected skin as well as in the lymph nodes of animals treated with IMQ.
|
29572462 |
2018 |
|
Rhinovirus infection
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
We then treated the ASM cells with the Toll-like receptor (TLR) agonists polyinosinic:polycytidylic acid, imiquimod, and pure RV RNA and were able to show that the mechanism through which RV induced ECM deposition was via the activation of TLR3 and TLR7/8.
|
21460120 |
2011 |
|
Arthritis
|
0.030 |
Biomarker
|
disease |
BEFREE |
We then showed that U11snRNA robustly activated the TLR7 pathway in vitro and induced arthritis disease in vivo.
|
31694883 |
2019 |
|
Secondary malignant neoplasm of colon and/or rectum
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We tested the hypothesis that genetic variations in TLR7 and TLR9 and their downstream molecules IRF5 and IRF7 were associated with outcomes in metastatic colorectal cancer (mCRC) patients receiving cetuximab-based chemotherapy.
|
28569041 |
2017 |
|
Myasthenia Gravis
|
0.020 |
Biomarker
|
disease |
BEFREE |
We suggested that TLR7/9 signaling may be involved in antiviral type I IFN production and long-term inflammation in EBV-infected MG thymuses.
|
26723518 |
2016 |
|
Lupus Erythematosus, Systemic
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
We suggest that TLR7 rs179008 and TLR9 rs5743836 can be considered SLE susceptibility factors for women of European descent in our population.
|
22065095 |
2012 |
|
Complete atrioventricular block
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
We studied the effect of TLR7 polymorphisms on disease susceptibility and progression of chronic hepatitis B (CHB) infection in Chinese adults.
|
28963470 |
2017 |
|
Hepatitis B, Chronic
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
We studied the effect of TLR7 polymorphisms on disease susceptibility and progression of chronic hepatitis B (CHB) infection in Chinese adults.
|
28963470 |
2017 |
|
Cystitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We studied TLR7 expression in the bladder of patients with Hunner-type IC (HIC) and its functional roles in bladder inflammation and nociception using mice.
|
28595240 |
2017 |
|
Asthma
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
We show that activation of pDCs through Toll-like receptor 7/8 suppresses ILC2-mediated AHR and airway inflammation and that depletion of pDCs reverses this suppression.
|
28579374 |
2018 |
|
Common Variable Immunodeficiency
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We show that TLR7- or 9-activated B cells from CVID subjects with >0.5% peripheral isotype-switched CD27(+) B cells (group 2) have increased mature Cγ1 and Cγ2 heavy-chain mRNA transcripts compared to subjects who have <0.5% isotype-switched cells (group 1).
|
22048980 |
2012 |
|
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We show here that miR-21 is an essential positive regulator for the production of both IFN-α and IFN-λ by pDCs and for promoting host defense against viral infection. miR-21 was markedly upregulated in toll-like receptor (TLR)-activated pDCs and was crucial for TLR7/9 ligand- or herpesvirus-induced production of IFN-α and IFN-λ by pDCs. miR-21-deficient pDCs produced significantly lower levels of IFN-α and IFN-λ on activation than those by wild-type pDCs.
|
28871250 |
2017 |
|
Hepatitis C
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We sequenced TLR7 in 52 women and investigated SNPs with an allele frequency >5% in 807 patients with chronic HCV-infection by melting curve analysis.
|
17512627 |
2007 |
|
Klinefelter Syndrome
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
We review here the current knowledge of the role of TLR7 in SLE, and recent evidence demonstrating that TLR7 escapes from X chromosome inactivation in pDCs, monocytes, and B lymphocytes from women and Klinefelter syndrome men.
|
30276444 |
2019 |
|
Klinefelter's syndrome - male with more than two X chromosomes
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
We review here the current knowledge of the role of TLR7 in SLE, and recent evidence demonstrating that TLR7 escapes from X chromosome inactivation in pDCs, monocytes, and B lymphocytes from women and Klinefelter syndrome men.
|
30276444 |
2019 |
|
Lupus Erythematosus, Systemic
|
0.300 |
Biomarker
|
disease |
BEFREE |
We review current studies of CNV in SLE susceptibility that include reports of association between SLE and CNV in C4, IgG Fc receptors, TLR7, and CCL3L1.
|
19287148 |
2008 |
|
IgE-mediated food allergy
|
0.010 |
Biomarker
|
disease |
BEFREE |
We proposed an oral administration strategy to treat FA by co-delivering food allergen epitope fragment (peptide: IK) and adjuvant R848 (TLR7 ligand) in the mPEG-PDLLA nanoparticles (PPLA-IK/R848 NPs).
|
31564865 |
2019 |